viewAmryt Pharma PLC

Amryt Pharma set to receive orphan designation for pre-clinical skin treatment

AP103 is being developed to treat dystrophic epidermolysis bullosa, a subset of epidermolysis bullosa, where the skin breaks at the merest touch

Amryt Pharma PLC -

Amryt Pharma PLC (NASDAQ: AMYT, LON:AMYT) looks set to receive orphan designation for its preclinical gene therapy for the rare skin condition dystrophic epidermolysis bullosa, which would provide the company with regulatory and financial incentives.

A European Medicines Agency (EMA) committee has delivered what’s called a “positive opinion” on the drug candidate, which is normally followed 30 days later by full ratification.

Orphan status is designed to aid the development and sign-off of life-threatening or chronically debilitating conditions affecting no more than five in 10,000 people. Incentives include ten years’ EU exclusivity following approval.

"Receiving this positive opinion from the EMA for our gene-therapy candidate, AP103, is a significant development for patients suffering from epidermolysis bullosa and provides additional momentum to our development pipeline,” Amryt chief executive, Dr Joe Wiley said in a statement.

Unlike other gene therapies that rely on viral vectors, the company’s technology is based on a polymer-based delivery platform that can be applied directly to the affected area.

This, Amryt believes, offers up the prospect that it can be used for other genetic skin conditions.

AP103 will follow in the slipstream of FILSUVEZ for epidermolysis bullosa, which successfully negotiated phase III clinical trials recently.

“These milestones relating to our efforts in epidermolysis bullosa are significant for all Amryt stakeholders as we build a global epidermolysis bullosa franchise and become a leader in rare and orphan diseases," said CEO Wiley.

Amryt said it expects to initiate clinical development of AP103 in the first half of 2022.

Quick facts: Amryt Pharma PLC

Price: 196 GBX

Market: AIM
Market Cap: £319.09 m


The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of Amryt Pharma PLC named herein, including the promotion by the Company of Amryt Pharma PLC in any Content on the Site, the Company receives from...



Amryt Pharma reports record Q3 2020 results, delivering 19% year on year growth

Amryt Pharma's LON:AMYT) Joe Wiley talks to Proactive New York's Christine Corrado about their latest record Q3 2020 Results. The results have lead to the full year guidance being raised which Wiley puts down to two launched commercial assents, metreleptin and lomitapide. Wiley talks...

3 weeks, 4 days ago

2 min read